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Sanjeevani Path Labs

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Double Marker

Double Marker

Pre test Information : No Special Preparation Needed


The first trimester screening is a more thorough screening that includes the double marker test, commonly known as maternal serum screening. It isn't a conclusive test. As a predictive test, however, it reports the chance of chromosomal abnormalities in the findings of the test.

This test specifically checks blood levels of pregnancy-associated plasma protein A and free beta-human chorionic gonadotrophin (beta-hCG) (PAPP-A).

In a typical pregnancy, male or female fetuses will have 22 pairs of XX chromosomes or 22 pairs of XY chromosomes.

An additional chromosome is present in a person with a trisomy, which includes the following conditions:

  • Down syndrome. Due to the extra copy of chromosome 21, this common trisomy is also known as trisomy 21.
  • Trisomy 13 and 18 are related. A second copy of either chromosome 18 (Edward's syndrome) or chromosome 13 (Patau's syndrome) is present in these typical chromosomal abnormalities.

These chromosomal anomalies can cause hCG and PAPP-A levels to be either higher or lower than "normal" in pregnancies.

Blood levels, however, do not alone result in your findings. Instead, a nuchal translucency (NT) scan, an ultrasound that looks at the transparent tissue at the back of your baby's neck, is combined with the blood test.



Report Delivery : Same Day Delivery

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